Adenovirus DNA replication in vitro.

  title={Adenovirus DNA replication in vitro.},
  author={Mark D Challberg and Thomas B Kelly},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={76 2},
A soluble extract from the nuclei of HeLa cells infected with adenovirus 5 (Ad5) carries out the semiconservative replication of exogenously added Ad5 DNA in vitro. Maximal DNA synthesis is observed when DNA-protein complex, isolated from Ad5 virions, is added as template. DNA-protein complex from virions of the closely related virus, adenovirus 2, is also active. In contrast, very little in vitro DNA synthesis is observed when deproteinized Ad5 DNA or DNA from a heterologous source… CONTINUE READING
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