Adenovirus-5 E1A: paradox and paradigm

  title={Adenovirus-5 E1A: paradox and paradigm},
  author={Steven M Frisch and Joe S. Mymryk},
  journal={Nature Reviews Molecular Cell Biology},
The adenovirus early region 1A (E1A) proteins were described originally as immortalizing oncoproteins that altered transcription in rodent cells. Surprisingly, the 243-amino-acid form of adenovirus-5 E1A was found subsequently to reverse-transform many human tumour cells. Tumour suppression apparently results from the ability of E1A to re-programme transcription in tumour cells, and the molecular basis of this intriguing effect is now beginning to emerge. These discoveries have provided a tool… 

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Adenovirus type 5 E1A gene products act as transformation suppressors of the neu oncogene

Results demonstrate that the E1A gene products can act negatively to suppress the transformed phenotype in neu-transformed cells.

Antioncogenic effect of adenovirus E1A in human tumor cells.

  • S. Frisch
  • Biology
    Proceedings of the National Academy of Sciences of the United States of America
  • 1991
The apparent paradox accorded by the observations of the ability of E1A to transform rodent cells in cooperation with other oncogenes suggests that E 1A may be the prototype of a class of growth-regulatory proteins having context-specific transforming and antioncogenic activities.

Adenovirus E1A protein paradigm viral transactivator.

This review focuses on the mechanism underlying the promiscuous transactivation activity of the E1A protein.

A p300/CBP-associated factor that competes with the adenoviral oncoprotein E1A

A new cellular p300/CBP-associated factor (P/CAF) having intrinsic histone acetylase activity has been identified that competes with E1A, a new adenoviral oncoprotein that induces progression through the cell cycle by binding to the products of the p300 and retinoblastoma gene families.

The adenovirus E1A proteins induce apoptosis, which is inhibited by the E1B 19-kDa and Bcl-2 proteins.

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Adenovirus E1A: remodelling the host cell, a life or death experience

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