Adenovirus-5 E1A: paradox and paradigm

@article{Frisch2002Adenovirus5EP,
  title={Adenovirus-5 E1A: paradox and paradigm},
  author={Steven M Frisch and Joe S. Mymryk},
  journal={Nature Reviews Molecular Cell Biology},
  year={2002},
  volume={3},
  pages={441-452}
}
The adenovirus early region 1A (E1A) proteins were described originally as immortalizing oncoproteins that altered transcription in rodent cells. Surprisingly, the 243-amino-acid form of adenovirus-5 E1A was found subsequently to reverse-transform many human tumour cells. Tumour suppression apparently results from the ability of E1A to re-programme transcription in tumour cells, and the molecular basis of this intriguing effect is now beginning to emerge. These discoveries have provided a tool… 

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References

SHOWING 1-10 OF 149 REFERENCES

Tumour suppressive properties of the adenovirus 5 E1A oncogene.

This review focuses on the surprising ability of E1A to function as a tumour suppressor gene.

Adenovirus e1a proteins and transformation (review).

What is known of the ways E1A interferes with growth regulation by these and other cellular proteins, such as cyclins and transcription factors, so as to bring about oncogenic transformation is described.

Adenovirus type 5 E1A gene products act as transformation suppressors of the neu oncogene

Results demonstrate that the E1A gene products can act negatively to suppress the transformed phenotype in neu-transformed cells.

Antioncogenic effect of adenovirus E1A in human tumor cells.

  • S. Frisch
  • Biology
    Proceedings of the National Academy of Sciences of the United States of America
  • 1991
The apparent paradox accorded by the observations of the ability of E1A to transform rodent cells in cooperation with other oncogenes suggests that E 1A may be the prototype of a class of growth-regulatory proteins having context-specific transforming and antioncogenic activities.

Adenovirus E1A protein paradigm viral transactivator.

This review focuses on the mechanism underlying the promiscuous transactivation activity of the E1A protein.

A p300/CBP-associated factor that competes with the adenoviral oncoprotein E1A

A new cellular p300/CBP-associated factor (P/CAF) having intrinsic histone acetylase activity has been identified that competes with E1A, a new adenoviral oncoprotein that induces progression through the cell cycle by binding to the products of the p300 and retinoblastoma gene families.

The adenovirus E1A proteins induce apoptosis, which is inhibited by the E1B 19-kDa and Bcl-2 proteins.

E1A-dependent stimulation of cell proliferation is accompanied by apoptosis and thereby insufficient to singly induce transformation, and high-frequency transformation requires a second function encoded by the E1B 19-kDa protein to block apoptosis.

Adenovirus early region 1A enables viral and cellular transforming genes to transform primary cells in culture

The polyoma virus middle-T and the T24 Harvey ras1 genes are individually unable to transform primary baby rat kidney cells and separate establishment and transforming functions are required for oncogenic transformation of primary cells in culture.

Adenovirus E1A: remodelling the host cell, a life or death experience

Around this time tissue culture studies revealed that rodent cells were susceptible to adenovirus transformation and that both tumorigenic and non-tumorigenic Ads induced morphological transformation from which immortal cell lines could be easily derived.

Promoter targeting by adenovirus E1a through interaction with different cellular DNA-binding domains

It is shown that E1a can interact with several classes of cellular DNA-binding domains and thereby be recruited to diverse promoters and explain how a single protein can regulate transcription of multiple genes that lack a common promoter element.
...