Adenoviral vectors for mucosal vaccination against infectious diseases.

  title={Adenoviral vectors for mucosal vaccination against infectious diseases.},
  author={Michael Santosuosso and Sarah B McCormick and Zhou Xing},
  journal={Viral immunology},
  volume={18 2},
Adenoviral vector has been extensively studied as a vaccine platform because of its ability to induce potent cellular and humoral immunity. One main advantage of adenoviral vectors is their natural tropism for mucosal surfaces, which makes them ideal for the purpose of mucosal vaccination against pathogens that preferentially initiate infection at the mucosal site. The current understanding of mucosal immunity suggests that mucosal vaccination is far superior to parenteral vaccination in… CONTINUE READING