Adenoviral transfer of human interleukin-10 gene in lethal pancreatitis.

  title={Adenoviral transfer of human interleukin-10 gene in lethal pancreatitis.},
  author={Zehava Chen and Yao-qing Tang and Yi Zhang and Zhi-hong Jiang and En-Qiang Mao and Wei-guo Zou and Ruo-qing Lei and Tian-quan Han and Sheng-dao Zhang},
  journal={World journal of gastroenterology},
  volume={10 20},
AIM To evaluate the therapeutic effect of adenoviral-vector-delivered human interleukin-10 (hIL-10) gene on severe acute pancreatitis (SAP) rats. METHODS Healthy Sprague-Dawley (SD) rats were intraperitoneally injected with adenoviral IL-10 gene (AdvhIL-10), empty vector (Adv0) or PBS solution. Blood, liver, pancreas and lung were harvested on the second day to examine hIL-10 level by ELISA and serum amylase by enzymatic assay. A SAP model was induced by retrograde injection of sodium… CONTINUE READING