Adenoviral transfer of HSP-70 into pulmonary epithelium ameliorates experimental acute respiratory distress syndrome.

@article{Weiss2002AdenoviralTO,
  title={Adenoviral transfer of HSP-70 into pulmonary epithelium ameliorates experimental acute respiratory distress syndrome.},
  author={Yoram George Weiss and Alina Maloyan and John Tazelaar and Nichelle N Raj and Clifford S. Deutschman},
  journal={The Journal of clinical investigation},
  year={2002},
  volume={110 6},
  pages={801-6}
}
The acute respiratory distress syndrome (ARDS) provokes three pathologic processes: unchecked inflammation, interstitial/alveolar protein accumulation, and destruction of pulmonary epithelial cells. The highly conserved heat shock protein HSP-70 can limit all three responses but is not appropriately expressed in the lungs after cecal ligation and double puncture (2CLP), a clinically relevant model of ARDS. We hypothesize that restoring expression of HSP-70 using adenovirus-mediated gene therapy… CONTINUE READING

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References

Publications referenced by this paper.
Showing 1-10 of 41 references

Anti-inflammatory effect of heat shock protein induction is related to stabilization of I kappa B alpha through preventing I kappa B kinase activation in respiratory epithelial cells

  • Yoo, G.C
  • J. Immunol
  • 2000
1 Excerpt

Sizedependent disaggregation of stable protein aggregates by the DnaK chaperone machinery

  • S. Diamant, A. Peres-Ben-Zvi, B. Bukau, P. Goloubinoff
  • J. Biol
  • 2000
1 Excerpt

Decreased transcription of surfactant proteins in an animal model of the adult respiratory distress syndrome ( ARDS )

  • K. M. Andrejko, J. Chen, C. S. Deutschman
  • Shock .
  • 1999

Decreased transcription of surfactant proteins in an animal model of the adult respiratory distress syndrome (ARDS). Shock

  • G. Schears, J. Zheng, C. Deutschman
  • 1999

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