Adenoviral transfer of HIF-1alpha enhances vascular responses to critical limb ischemia in diabetic mice.

@article{Sarkar2009AdenoviralTO,
  title={Adenoviral transfer of HIF-1alpha enhances vascular responses to critical limb ischemia in diabetic mice.},
  author={Kakali Sarkar and Karen Fox-Talbot and Charles Steenbergen and Marta Bosch-Marc{\'e} and Gregg L Semenza},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2009},
  volume={106 44},
  pages={18769-74}
}
Diabetes is a major risk factor for ischemic disease. Treatment options for diabetic patients with peripheral arterial disease when revascularization is not possible are limited, resulting in a high incidence of limb amputation. We evaluated the therapeutic potential of AdCA5, an adenovirus encoding a constitutively active form of HIF-1alpha, in a diabetic model of critical limb ischemia. Diabetic db/db and nondiabetic db/+ mice were subjected to unilateral femoral artery ligation. Limb… CONTINUE READING