Adenoviral proteins mimic nutrient/growth signals to activate the mTOR pathway for viral replication.

@article{OShea2005AdenoviralPM,
  title={Adenoviral proteins mimic nutrient/growth signals to activate the mTOR pathway for viral replication.},
  author={Clodagh C O'Shea and Kristina Klupsch and Serah Choi and Bridget Bagus and Conrado Soria and Jerry Y Shen and Frank Mccormick and David Stokoe},
  journal={The EMBO journal},
  year={2005},
  volume={24 6},
  pages={1211-21}
}
Like tumor cells, DNA viruses have had to evolve mechanisms that uncouple cellular replication from the many intra- and extracellular factors that normally control it. Here we show that adenovirus encodes two proteins that activate the mammalian target of rapamycin (mTOR) for viral replication, even under nutrient/growth factor-limiting conditions. E4-ORF1 mimics growth factor signaling by activating PI3-kinase, resulting in increased Rheb.GTP loading and mTOR activation. E4-ORF4 is redundant… CONTINUE READING

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Inaugural article : the tumor suppressor LKB 1 kinase directly activates AMPactivated kinase and regulates apoptosis in response to energy stress

  • V Taylor, M Wong, +5 authors D Stokoe
  • Proc Natl Acad Sci USA
  • 2004

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