Adenoviral-mediated overexpression of monocyte chemoattractant protein-1 differentially alters the development of Th1 and Th2 type responses in vivo.

@article{Matsukawa2000AdenoviralmediatedOO,
  title={Adenoviral-mediated overexpression of monocyte chemoattractant protein-1 differentially alters the development of Th1 and Th2 type responses in vivo.},
  author={Akihiro Matsukawa and Nicholas W Lukacs and Thedodore J. Standiford and Stephen W. Chensue and Steven L. Kunkel},
  journal={Journal of immunology},
  year={2000},
  volume={164 4},
  pages={1699-704}
}
The expression of chemokines during an immune response may participate in determining the intensity and type of the developing immune response. In the present study, we have examined the effect of overexpressing monocyte chemoattractant protein (MCP)-1 at the site of immunization during different stages of Th1- and Th2-type granulomatous responses. The overexpression of MCP-1 by MCP-1 adenovirus during the sensitization phase of the purified protein derivative Th1-type model significantly… CONTINUE READING