Adenoviral-mediated gene transfer of human bone morphogenetic protein-13 does not improve rotator cuff healing in a rat model.

@article{Gulotta2011AdenoviralmediatedGT,
  title={Adenoviral-mediated gene transfer of human bone morphogenetic protein-13 does not improve rotator cuff healing in a rat model.},
  author={Lawrence Vincent Gulotta and David Kovacevic and Jonathan D. Packer and John R. Ehteshami and Scott Alan Rodeo},
  journal={The American journal of sports medicine},
  year={2011},
  volume={39 1},
  pages={180-7}
}
BACKGROUND Rotator cuff tendon-to-bone healing occurs by formation of a scar tissue interface after repair, which makes it prone to failure. Bone morphogenetic protein-13 (BMP-13) has been implicated in tendon and cartilage repair, and thus may augment rotator cuff repairs. The purpose of this study was to determine if the application of mesenchymal stem cells (MSCs) transduced with BMP-13 could improve regeneration of the tendon-bone insertion site in a rat rotator cuff repair model… CONTINUE READING

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