Adenoviral-mediated gene transfer of a constitutively active form of the retinoblastoma gene product attenuates neointimal thickening in experimental vein grafts.

@article{Schwartz1999AdenoviralmediatedGT,
  title={Adenoviral-mediated gene transfer of a constitutively active form of the retinoblastoma gene product attenuates neointimal thickening in experimental vein grafts.},
  author={Lewis B Schwartz and J Moawad and Eric C. Svensson and Rachel Tufts and Shari L. Meyerson and D A Baunoch and Jeffrey M. Leiden},
  journal={Journal of vascular surgery},
  year={1999},
  volume={29 5},
  pages={874-81; discussion 882-3}
}
PURPOSE Inappropriate or excessive vascular smooth muscle cell proliferation leads to the development of occlusive lesions in up to 50% of vein grafts. The purpose of this study was to test the hypothesis that induced overexpression of a cytostatic nonphosphorylatable form of the retinoblastoma protein (DeltaRb) would attenuate neointimal thickening in… CONTINUE READING