Adenoviral-mediated Delivery of an Anti-ras Ribozyme Neoplastic Reversion Accomplished by High Efficiency Updated

Strategies have been developed to abrogate the aberrant expression of dominant oncogenes as a means to accomplish targeted tumor eradication. We have demonstrated previously the utility of this approach using a hammerhead ribozyme designed to cleave the mutant sequence in codon 12 of the activated H-ras oncogene transcript. To develop this strategy into a… CONTINUE READING