Adenoviral gene transfer of interleukin-1 in combination with oncostatin M induces significant joint damage in a murine model.

@article{Rowan2003AdenoviralGT,
  title={Adenoviral gene transfer of interleukin-1 in combination with oncostatin M induces significant joint damage in a murine model.},
  author={Andrew D Rowan and Wang Xu Hui and Timothy E Cawston and Carl D Richards},
  journal={The American journal of pathology},
  year={2003},
  volume={162 6},
  pages={1975-84}
}
Oncostatin M (OSM) is an interleukin (IL)-6 family cytokine that we have previously shown can synergize with a number of proinflammatory cytokines to promote the release of collagen from cartilage in explant culture. However, the effects of this potent cytokine combination in vivo are not known. Using adenoviral gene transfer, we have overexpressed murine IL-1 (AdmIL-1) and murine OSM (AdmOSM) intraarticularly in the knees of C57BL/6 mice. Histological analyses indicated marked synovial… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 29 extracted citations

Similar Papers

Loading similar papers…