Adenoviral expression of p53 represses telomerase activity through down-regulation of human telomerase reverse transcriptase transcription.

@article{Kanaya2000AdenoviralEO,
  title={Adenoviral expression of p53 represses telomerase activity through down-regulation of human telomerase reverse transcriptase transcription.},
  author={Taro Kanaya and Satoru Kyo and Kazunori Hamada and Masahiro Takakura and Yuko Kitagawa and Hisashi Harada and Masatoshi Inoue},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2000},
  volume={6 4},
  pages={1239-47}
}
Telomerase activation is a critical step in cellular immortality and oncogenesis. The activity of telomerase is known to be correlated with cell proliferation, but its regulation by cell cycle regulators is not well understood. In the present study, we examined the effects of p53 on telomerase activity. Wild-type p53 was introduced into SiHa cells via a recombinant adenoviral vector, Ad5CMV-p53, and change in telomerase activity was examined by quantitative telomerase assay. Telomerase activity… CONTINUE READING
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WAF 1 , a potential mediator of p 53 tumor suppression

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