Adenoviral Gene Transfer of PLD1-D4 Enhances Insulin Sensitivity in Mice by Disrupting Phospholipase D1 Interaction with PED/PEA-15

@inproceedings{Cassese2013AdenoviralGT,
  title={Adenoviral Gene Transfer of PLD1-D4 Enhances Insulin Sensitivity in Mice by Disrupting Phospholipase D1 Interaction with PED/PEA-15},
  author={Angela Cassese and Gregory Alexander Raciti and Francesca Serraino Fiory and Cecilia Nigro and Luca Ulianich and Ilenia Castan{\`o} and Vittoria D’Esposito and Daniela Terracciano and Lucio Pastore and Pietro Formisano and Francesco B{\'e}guinot and Claudia Miele},
  booktitle={PloS one},
  year={2013}
}
Over-expression of phosphoprotein enriched in diabetes/phosphoprotein enriched in astrocytes (PED/PEA-15) causes insulin resistance by interacting with the D4 domain of phospholipase D1 (PLD1). Indeed, the disruption of this association restores insulin sensitivity in cultured cells over-expressing PED/PEA-15. Whether the displacement of PLD1 from PED/PEA-15 improves insulin sensitivity in vivo has not been explored yet. In this work we show that treatment with a recombinant adenoviral vector… CONTINUE READING