Adenoviral E1B55K oncoprotein sequesters candidate leukemia suppressor sequence-specific single-stranded DNA-binding protein 2 into aggresomes

@article{Fleisig2007AdenoviralEO,
  title={Adenoviral E1B55K oncoprotein sequesters candidate leukemia suppressor sequence-specific single-stranded DNA-binding protein 2 into aggresomes},
  author={Helen B Fleisig and Nicole I. Orazio and Hong Liang and Andrew F. Tyler and Henry P. Adams and Matthew D Weitzman and Lalitha Nagarajan},
  journal={Oncogene},
  year={2007},
  volume={26},
  pages={4797-4805}
}
Sequence-specific single-stranded DNA-binding protein 2 (SSBP2) is a candidate tumor suppressor for human acute myelogenous leukemia (AML). Inducible expression of SSBP2 causes growth arrest and partial differentiation in AML cells. Here, we report that the adenoviral oncoprotein E1B55K directly binds to endogenous SSBP2 protein and sequesters it into juxtanuclear bodies in adenovirally transformed human embryonic kidney (HEK) 293 cells. Similarly, transient expression of E1B55K in IMR90… CONTINUE READING
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Analysis of the adenovirus E1B-55K-anchored proteome reveals its link to ubiquitination machinery

  • JN Harada, A Shevchenko, DC Pallas, AJ. Berk
  • J Virol
  • 2002
Highly Influential
5 Excerpts

Ssdp proteins

  • L Chen, D Segal, NA Hukriede, AV Podtelejnikov, D Bayarsaihan, JA Kennison
  • 2002
Highly Influential
4 Excerpts

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