Corpus ID: 46749240

Adenotin and adenotin-like proteins coexist with adenosine receptors in mammalian tissues.

@article{Work1991AdenotinAA,
  title={Adenotin and adenotin-like proteins coexist with adenosine receptors in mammalian tissues.},
  author={C. Work and S. Zołnierowicz and K. A. Hutchinson and M. Prasad and I. Fox},
  journal={The Journal of laboratory and clinical medicine},
  year={1991},
  volume={117 3},
  pages={
          250-8
        }
}
The relationship of adenotin, a low-affinity adenosine-binding protein, to adenosine receptors was examined in two human tissues and two mammalian cultured cell lines. An adenosine A2 receptor exists in the membranes from platelets, PC-12 cells, and JAR cells as shown by a stimulation of adenylate cyclase related to 5'-N-ethylcarboxamidoadenosine (NECA) or a NECA-related increase in intracellular cAMP levels. In contrast, binding studies with tritiated NECA revealed typical adenotin-like low… Expand
8 Citations