Adenosine triphosphate inhibits endothelin-1 production by rat inner medullary collecting duct cells.

@article{Hughes2006AdenosineTI,
  title={Adenosine triphosphate inhibits endothelin-1 production by rat inner medullary collecting duct cells.},
  author={Alisa K Hughes and Peter K. Stricklett and Bellamkonda K Kishore and Donald E Kohan},
  journal={Experimental biology and medicine},
  year={2006},
  volume={231 6},
  pages={
          1006-9
        }
}
Adenosine triphosphate (ATP) and endothelin (ET)-1 inhibit vasopressin-stimulated water reabsorption in the inner medullary collecting duct (IMCD). Because both ATP and ET-1 are released by the IMCD and can act in an autocrine manner to regulate IMCD water transport, we sought to determine whether these factors can modulate the other's production. To begin such studies, the effect of ATP on IMCD ET-1 production was examined. ATP caused a dose-dependent inhibition of ET-1 release and inhibited… CONTINUE READING

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