Adenosine triphosphate depletion induces a rise in cytosolic free calcium in canine renal epithelial cells.

@article{Mccoy1988AdenosineTD,
  title={Adenosine triphosphate depletion induces a rise in cytosolic free calcium in canine renal epithelial cells.},
  author={Chris Mccoy and A M Selvaggio and E Alexenskii Alexander and John H. Schwartz},
  journal={The Journal of clinical investigation},
  year={1988},
  volume={82 4},
  pages={
          1326-32
        }
}
An elevation in cytosolic free calcium (Cai) produced by cellular ATP depletion may contribute to the initiation of cytotoxic events in renal ischemia. To evaluate whether ATP depletion results in a rise in Cai we examined the effect of cyanide and 2-deoxy-D-glucose on the Cai of Madin-Darby canine kidney cells. Exposure to the metabolic inhibitors resulted in a rise in Cai from 112 +/- 11 to 649 +/- 99 nM in 15 min. This combination of metabolic inhibitors also resulted in a decrement of cell… CONTINUE READING
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