Adenosine stimulates angiogenesis by up-regulating production of thrombospondin-1 by macrophages.

@article{Ernens2015AdenosineSA,
  title={Adenosine stimulates angiogenesis by up-regulating production of thrombospondin-1 by macrophages.},
  author={Isabelle Ernens and M{\'e}lanie Bousquenaud and B{\'e}n{\'e}dicte Lenoir and Yvan Devaux and Daniel R. Wagner},
  journal={Journal of leukocyte biology},
  year={2015},
  volume={97 1},
  pages={9-18}
}
Increase of blood capillary density at the interface between normal and ischemic tissue after acute MI reduces infarct size and improves cardiac function. Cardiac injury triggers the production of the matricellular component TSP-1, but its role in angiogenesis is not clear, as both anti- and proangiogenic properties have been reported. It is unknown whether… CONTINUE READING