Adenosine-sensitive afterdepolarizations and triggered activity in guinea pig ventricular myocytes.

@article{Song1992AdenosinesensitiveAA,
  title={Adenosine-sensitive afterdepolarizations and triggered activity in guinea pig ventricular myocytes.},
  author={Y Song and S S Thedford and B B Lerman and L Belardinelli},
  journal={Circulation research},
  year={1992},
  volume={70 4},
  pages={743-53}
}
  • Y Song, S S Thedford, +1 author L Belardinelli
  • Published 1992 in Circulation research
This study examines the cellular basis and specificity of the effects of adenosine on early afterdepolarizations (EADs), delayed afterdepolarizations (DADs), and triggered activity (TA) induced by various drugs with different mechanisms of action. Membrane potential and currents were measured in isolated guinea pig ventricular myocytes. Adenosine (10-100 microM) significantly (p less than 0.05) reduced the amplitude of DADs and suppressed TA induced by isoproterenol (10-50 nM) and forskolin (1… CONTINUE READING