Adenosine selectively depresses muscarinic compared with non-muscarinic receptor mediated depolarisation of the rat superior cervical ganglion.

@article{Connolly1995AdenosineSD,
  title={Adenosine selectively depresses muscarinic compared with non-muscarinic receptor mediated depolarisation of the rat superior cervical ganglion.},
  author={Gerald P. Connolly and Trevor W. Stone},
  journal={General pharmacology},
  year={1995},
  volume={26 4},
  pages={
          865-73
        }
}
1. A grease gap d.c. recording technique was used to measure electrophysiological responses of the isolated rat superior cervical ganglion. 2. Adenosine at 100 microM depressed depolarisations to the muscarinic agonists carbachol, muscarine and methylfurmethide. In contrast adenosine (100 microM) did not alter depolarisations to 1,1-dimethyl-4-phenylpiperazinium, 2-methyl-5-hydroxytryptamine and potassium and enhanced depolarisations to 5-hydroxytryptamine and gamma-aminobutyric acid. 3… Expand
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Evidence is provided that synaptically released GABA activates GABAB receptors that inhibit mAChR‐mediated EPSPs in hippocampal CA1 pyramidal neurones and the mechanism of inhibition may involve both pre− and postsynaptic elements. Expand
Regulation of muscarinic acetylcholine receptor‐mediated synaptic responses by adenosine receptors in the rat hippocampus
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Ecto-nucleotidase of cultured rat superior cervical ganglia: dipyridamole is a novel inhibitor.
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It is indicated that rat superior cervical ganglia possess ecto-nucleotidases capable of catabolising purine and pyrimidine nucleotides to their nucleosides, and that dipyridamole is a potent inhibitor of ectosine-beta-arabinoside activity. Expand

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