Adenosine released by astrocytes contributes to hypoxia-induced modulation of synaptic transmission.

@article{Martn2007AdenosineRB,
  title={Adenosine released by astrocytes contributes to hypoxia-induced modulation of synaptic transmission.},
  author={Eduardo D. Mart{\'i}n and Miriam Fern{\'a}ndez and Gertrudis Perea and Olivier Pascual and Philip Haydon and Alfonso Araque and Valent{\'i}n Ce{\~n}a},
  journal={Glia},
  year={2007},
  volume={55 1},
  pages={36-45}
}
Astrocytes play a critical role in brain homeostasis controlling the local environment in normal as well as in pathological conditions, such as during hypoxic/ischemic insult. Since astrocytes have recently been identified as a source for a wide variety of gliotransmitters that modulate synaptic activity, we investigated whether the hypoxia-induced excitatory synaptic depression might be mediated by adenosine release from astrocytes. We used electrophysiological and Ca2+ imaging techniques in… CONTINUE READING

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