Adenosine regulates tissue factor expression on endothelial cells.

  title={Adenosine regulates tissue factor expression on endothelial cells.},
  author={Hiroko Deguchi and Hiroyuki Takeya and Hiroko Urano and Esteban Cesar Gabazza and Huarong Zhou and Koji A. O. Suzuki},
  journal={Thrombosis research},
  volume={91 2},
The aim of this study was to evaluate the inhibitory activity of adenosine on tumor necrosis factor-alpha (TNF), thrombin-, or phorbol 12-myristate 13-acetate (PMA)-induced tissue factor (TF) expression on human umbilical vein endothelial cells (HUVECs). This inhibitory effect of adenosine was found to be counteracted by the non-selective adenosine receptor (AR) antagonist, 8-(p-sulfophenyl) theophylline. To clarify the role of ARs (A1, A2a, A2b, and A3) in this regulation, we evaluated the… CONTINUE READING