Adenosine receptors mediate glutamate-evoked arteriolar dilation in the rat cerebral cortex.

@article{Iliff2003AdenosineRM,
  title={Adenosine receptors mediate glutamate-evoked arteriolar dilation in the rat cerebral cortex.},
  author={Jeffrey J. Iliff and Raimondo D’Ambrosio and Al C. Ngai and H. Richard Winn},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2003},
  volume={284 5},
  pages={
          H1631-7
        }
}
We tested the hypothesis that adenosine (Ado) mediates glutamate-induced vasodilation in the cerebral cortex by monitoring pial arteriole diameter in chloralose-anesthetized rats equipped with closed cranial windows. Topical application of 100 microM glutamate and 100 microM N-methyl-d-aspartate (NMDA) dilated pial arterioles (baseline diameter 25 +/- 2 microm) by 17 +/- 1% and 18 +/- 4%, respectively. Coapplication of the nonselective Ado receptor antagonist theophylline (Theo; 10 microM… 
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