Adenosine receptors in post-mortem human cerebral cortex and the effect of carbamazepine.

@article{Dodd1986AdenosineRI,
  title={Adenosine receptors in post-mortem human cerebral cortex and the effect of carbamazepine.},
  author={Peter Ronald Dodd and Wendy E. J. Watson and Graham A. R. Johnston},
  journal={Clinical and experimental pharmacology & physiology},
  year={1986},
  volume={13 10},
  pages={711-22}
}
Representative A1 site- and A2 site-selective ligands for adenosine receptors were found to bind to a single class of non-co-operative sites in synaptic membranes prepared from pieces of normal human temporal lobe cerebral cortex obtained at autopsies performed within 24 h post-mortem. The known adenosine antagonists theophylline and 1-isobutyl-3-methylxanthine also bound to these sites and could completely displace either ligand. Computer analysis combining data from 21 separate experiments… CONTINUE READING

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