Adenosine receptors co-operate with NMDA preconditioning to protect cerebellar granule cells against glutamate neurotoxicity.

@article{Boeck2005AdenosineRC,
  title={Adenosine receptors co-operate with NMDA preconditioning to protect cerebellar granule cells against glutamate neurotoxicity.},
  author={Carina Rodrigues Boeck and Eduardo H Kroth and Mauro J Bronzatto and Deusa Aparecida Vendite},
  journal={Neuropharmacology},
  year={2005},
  volume={49 1},
  pages={17-24}
}
N-Methyl-D-aspartate (NMDA) preconditioning is evoked by subtoxic concentrations of NMDA (50 microM), which has been shown previously to lead to transient resistance to subsequent lethal dose of glutamate or NMDA in cultured neurons. The purpose of this study was to investigate the participation of adenosine A1 and A2A receptors on NMDA preconditioning against glutamate-induced cellular damage in cerebellar granule cells. NMDA preconditioning prevented the stimulatory effect induced by… CONTINUE READING
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