Adenosine receptors: G protein-mediated signalling and the role of accessory proteins.

@article{Klinger2002AdenosineRG,
  title={Adenosine receptors: G protein-mediated signalling and the role of accessory proteins.},
  author={Markus Klinger and Michael Freissmuth and Christian Nanoff},
  journal={Cellular signalling},
  year={2002},
  volume={14 2},
  pages={99-108}
}
Ever since the discovery of the effects of adenosine in the circulation, adenosine receptors continue to represent a promising drug target. Firstly, this is due to the fact that the receptors are expressed in a large variety of cells; in particular, the actions of adenosine (or, respectively, of the antagonistic methylxanthines) in the central nervous system, in the circulation, on immune cells and on other tissues can be beneficial in certain disorders. Secondly, there exists a large number of… CONTINUE READING

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