Adenosine receptor subtypes in the heart: therapeutic opportunities and challenges.

FOUR SUBTYPES OF ADENOSINE RECEPTORS (A1, A2A, A2B, and A3 receptors) are known to exist (26). Traditionally, the A1-adenosine receptor has been thought to be the only subtype expressed in ventricular cardiomyocytes. By inhibiting adenylyl cyclase, the A1 receptor attenuates the positive inotropic effect of b-adrenergic receptor stimulation (or other… (More)

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