Adenosine receptor-mediated modulation of dopamine release in the nucleus accumbens depends on glutamate neurotransmission and N-methyl-D-aspartate receptor stimulation.

@article{Quarta2004AdenosineRM,
  title={Adenosine receptor-mediated modulation of dopamine release in the nucleus accumbens depends on glutamate neurotransmission and N-methyl-D-aspartate receptor stimulation.},
  author={Davide Quarta and Janusz Borycz and Marcello Solinas and Kshitij A Patkar and J{\"o}rg Hockemeyer and Francisco Ciruela and Carme Llu{\'i}s and Rafael Franco and Amina S Woods and Steven R. Goldberg and Sergi Ferr{\'e}},
  journal={Journal of neurochemistry},
  year={2004},
  volume={91 4},
  pages={873-80}
}
Adenosine, by acting on adenosine A(1) and A(2A) receptors, exerts opposite modulatory roles on striatal extracellular levels of glutamate and dopamine, with activation of A(1) inhibiting and activation of A(2A) receptors stimulating glutamate and dopamine release. Adenosine-mediated modulation of striatal dopaminergic neurotransmission could be secondary to changes in glutamate neurotransmission, in view of evidence for a preferential colocalization of A(1) and A(2A) receptors in glutamatergic… CONTINUE READING
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