Adenosine receptor-mediated calcium mobilization in cortical collecting tubule cells.

@article{Arend1988AdenosineRC,
  title={Adenosine receptor-mediated calcium mobilization in cortical collecting tubule cells.},
  author={Lois J. Arend and Maria A Burnatowska-Hledin and William S. Spielman},
  journal={The American journal of physiology},
  year={1988},
  volume={255 5 Pt 1},
  pages={C581-8}
}
To investigate the cellular mechanisms underlying the epithelial actions of adenosine, we studied adenosine receptor-effector coupling in cultured rabbit cortical collecting tubule (RCCT) cells. We previously reported, in RCCT cells isolated by immunodissection, that a potent A2 adenosine analogue [5'-N-ethylcarboxamideadenosine (NECA)] stimulates cAMP production [effective concentration 50% (EC50) = 1 microM], and potent A1 analogues [N6-cyclohexyladenosine (CHA) and R-N6… CONTINUE READING

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