Adenosine receptor-mediated accumulation of adenosine 3',5'-monophosphate in guinea pig thyroid tissue.


The cAMP content of guinea pig thyroid fragments was increased 2- to 3-fold by adenosine analogs, 5'-N-ethylcarboxamide adenosine (NECA), the most potent, caused half-maximal stimulation of 0.7 microM, whereas N6-phenylisopropyl adenosine was much less potent (half-maximal stimulation at 20 microM). Exogenous adenosine by itself was slightly active, and its… (More)