Adenosine produces pulmonary vasodilation in the perfused rabbit lung via an adenosine A2 receptor.

@article{Pearl1994AdenosinePP,
  title={Adenosine produces pulmonary vasodilation in the perfused rabbit lung via an adenosine A2 receptor.},
  author={Ronald G. Pearl},
  journal={Anesthesia and analgesia},
  year={1994},
  volume={79 1},
  pages={46-51}
}
Adenosine is a potent pulmonary vasodilator that has been used in therapy for clinical and experimental pulmonary hypertension. To determine the receptor responsible for adenosine-induced pulmonary vasodilation, we studied the relative potency of four adenosine agonists in the isolated buffer-perfused rabbit lung during pulmonary hypertension due to infusion of the thromboxane A2 mimetic U46619. The ED50 values for pulmonary vasodilation were 1.9 x 10(-8) mol/L for 5'-N… CONTINUE READING

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