Adenosine prevents hyperkalemia-induced calcium loading in cardiac cells: relevance for cardioplegia.

@article{Jovanovi1997AdenosinePH,
  title={Adenosine prevents hyperkalemia-induced calcium loading in cardiac cells: relevance for cardioplegia.},
  author={Aleksandar Jovanovi{\'c} and Alexey Alekseev and Jos{\'e} Raul Lopez and Win Kuang Shen and Andre Terzic},
  journal={The Annals of thoracic surgery},
  year={1997},
  volume={63 1},
  pages={
          153-61
        }
}
BACKGROUND Hyperkalemic cardioplegic solutions effectively arrest the heart but also induce membrane depolarization, which could lead to intracellular Ca2+ loading and contribute to ventricular dysfunction associated with cardiac operations. Adenosine, which possesses cardioprotective properties, has been proposed as an adjunct to conventional cardioplegic solutions. However, it is not known whether adenosine supplementation enables cardiac cells to withstand hyperkalemia-induced Ca2+ loading… CONTINUE READING
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