Adenosine potentiation of neuromuscular blocking agents in guinea-pigs.

@article{Nitahara2000AdenosinePO,
  title={Adenosine potentiation of neuromuscular blocking agents in guinea-pigs.},
  author={Keiichi Nitahara and P. H. Kornak and H Nagashima and E. Sylvester Vizi and Francis F. Foldes and Kenjiro Dan},
  journal={British journal of anaesthesia},
  year={2000},
  volume={84 2},
  pages={
          245-7
        }
}
We have investigated the effects of adenosine i.v. on neuromuscular block induced by rocuronium, vecuronium and pipecuronium in an in vivo guinea-pig sciatic nerve-tibialis anterior preparation. The ED50 of each neuromuscular blocker was determined from cumulative log dose-response regression lines (n = 14). In separate experiments, adenosine 0.1 mg kg-1 min-1 or the same volume of 0.9% NaCl was given i.v. via a constant infusion and the ED50 of each neuromuscular blocking agent was then… Expand
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