Adenosine potentiates forskolin-induced delay of meiotic resumption by mouse denuded oocytes: evidence for an oocyte surface site of adenosine action.

@article{Salustri1988AdenosinePF,
  title={Adenosine potentiates forskolin-induced delay of meiotic resumption by mouse denuded oocytes: evidence for an oocyte surface site of adenosine action.},
  author={Antonietta Salustri and S Petrungaro and M. P{\'e}rez-D{\'i}az Conti and Gregorio Siracusa},
  journal={Gamete research},
  year={1988},
  volume={21 2},
  pages={157-68}
}
Adenosine is present in the mouse follicular fluid and has been shown to interfere with oocyte maturation in vitro. To clarify the mechanism of adenosine action on meiotic arrest, we have characterized the synergistic action of this purine with forskolin on the meiotic resumption of mouse denuded oocytes. Forskolin delays meiotic resumption by approximately 1 hour; adenosine at concentrations ranging between 30-750 microM has no significant effect. Conversely, adenosine treatment together with… CONTINUE READING