Adenosine modulation of amygdala kindling.

  title={Adenosine modulation of amygdala kindling.},
  author={Mike Dragunow and Graham V. Goddard},
  journal={Experimental neurology},
  volume={84 3},
To test the hypothesis that kindling is restrained by the inhibitory neuromodulator, adenosine, the adenosine uptake blocker, papaverine, or the adenosine antagonist, aminophylline, were injected systemically into rats 20 min before each daily electrical stimulation of the amygdala. The effects on amygdala-triggered seizures of papaverine, adenosine, 2-chloroadenosine, and the adenosine antagonists, isobutylmethylxanthine and caffeine, were also investigated at seizure threshold. Papaverine… CONTINUE READING