Adenosine modulates oesophageal sensorimotor function in humans

@article{RemesTroche2009AdenosineMO,
  title={Adenosine modulates oesophageal sensorimotor function in humans},
  author={Jose Mar{\'i}a Remes-Troche and Premjit S Chahal and Ranjit S. Mudipalli and S S Rao},
  journal={Gut},
  year={2009},
  volume={58},
  pages={1049 - 1055}
}
Background and aims: Adenosine mediates somatic and visceral pain, but its effects on gut visceral nociception are unknown. The aim of the present study was to test the hypothesis that adenosine alters oesophageal sensorimotor function. Methods: In a double-blind, randomised, placebo-controlled study, 14 healthy volunteers (M/F = 4/10) received either intravenous adenosine 100 μg/kg/min or placebo infusion. Prior to and during infusion, all subjects underwent stepwise graded oesophageal balloon… 
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References

SHOWING 1-10 OF 94 REFERENCES
Experimentally induced ischaemic pain in healthy humans is attenuated by the adenosine receptor antagonist theophylline.
TLDR
It is concluded that the adenosine receptor antagonist theophylline is able to attenuate the development of ischaemia pain during experimental ischaemic pain in humans, implying a role for adenosines as both facilitatory mediator and a modulator ofIschaemia skeletal muscle pain.
Imipramine decreases oesophageal pain perception in human male volunteers
TLDR
Increased pain thresholds on imipramine in this group of normal male volunteers in the absence of changes in oesophageal tone imply the presence of a visceral analgesic effect.
Muscular and cardiac adenosine-induced pain is mediated by A1 receptors.
An Open-Label Trial of Theophylline for Functional Chest Pain
TLDR
Theophylline may ameliorate chest pain in patients with hypersensitive esophagus, possibly by altering adenosine-mediated nociception.
The development and maintenance of human visceral pain hypersensitivity is dependent on the N-methyl-D-aspartate receptor.
TLDR
The induction and maintenance of acid-induced esophageal hypersensitivity is prevented and reversed by ketamine, which strongly indicates that central sensitization is a mechanism of visceral hypersensitivity.
Analgesic effect of bamiphylline on pain induced by intradermal injection of adenosine
Theophylline Improves Esophageal Chest Pain—A Randomized, Placebo-Controlled Study
TLDR
Theophylline relaxed the esophageal wall, decreased hypersensitivity, and improved chest pain, and is effective in the treatment of functional chest pain.
Sensitization to painful distention and abnormal sensory perception in the esophagus.
Functional chest pain of esophageal origin: hyperalgesia or motor dysfunction
TLDR
Hyperalgesia rather than motor dysfunction appears to be the predominant mechanism for functional chest pain of esophageal origin, at lower sensory thresholds than controls.
Adenosine injection into the brachial artery produces ischaemia like pain or discomfort in the forearm.
TLDR
It is concluded that the symptoms did not appear to be dependent on vasodilatation and therefore adenosine may contribute to ischaemic pain or discomfort.
...
...