Adenosine kinase and ribokinase – the RK family of proteins

@article{Park2008AdenosineKA,
  title={Adenosine kinase and ribokinase – the RK family of proteins},
  author={J. Park and R. Sen Gupta},
  journal={Cellular and Molecular Life Sciences},
  year={2008},
  volume={65},
  pages={2875-2896}
}
  • J. Park, R. Gupta
  • Published 14 June 2008
  • Biology, Computer Science, Chemistry
  • Cellular and Molecular Life Sciences
Abstract.Ribokinase (RK) and adenosine kinase (AK) catalyze the phosphorylation of ribose and adenosine to ribose-5-phosphate and AMP, respectively. Belonging to the RK family of proteins, these enzymes share a number of unique structural and functional elements. Extensive work has been carried out on many aspects of these enzymes in recent years, and we summarize the wealth of information currently available on them. The topics covered include descriptions of the primary and three-dimensional… 

Adenosine Metabolism, Adenosine Kinase, and Evolution

TLDR
Several important gaps exist in knowledge regarding ADK, particularly concerning the cellular functions of the two isoforms and how their relative amounts in different tissues are regulated, that need to be understood in order to fully realize the therapeutic potential of increased local concentration of adenosine by modulation of this key enzyme.

Chapter 2 Adenosine Metabolism , Adenosine Kinase , and Evolution

TLDR
This chapter summarizes the wealth of information that has accumulated concerning adenosine kinase and discusses the cellular functions of the two isoforms and how their relative amounts in different tissues are regulated.

A subfamily of bacterial ribokinases utilizes a hemithioacetal for pyridoxal phosphate salvage.

TLDR
Insight is provided into an unprecedented dual Cys charge relay network that is mandatory for PL phosphorylation and serves as a characteristic mechanistic feature for a dual-function ribokinase subfamily herein termed CC-PLKs.

A putative adenosine kinase family protein possesses adenosine diphosphatase activity

TLDR
This study provides the first experimental evidence for the enzymatic function of the “adenosine-specific kinase” family and suggests a need to reexamine its functional annotation.

Mycobacterial adenosine kinase is not a typical adenosine kinase

Adenosine Kinase: Exploitation for Therapeutic Gain

TLDR
This review will provide a comprehensive overview of the genetics, biochemistry, and pharmacology of ADK and will then focus on pathologies and therapeutic interventions.

Purine salvage in plants.

Crystallization and preliminary X-ray analysis of a ribokinase from Vibrio cholerae O395.

Ribokinase (RK) is one of the principal enzymes in carbohydrate metabolism, catalyzing the reaction of D-ribose and adenosine triphosphate to produce ribose-5-phosphate and adenosine diphosphate

Comparative genomic and expression analysis of the adenosine signaling pathway members in Xenopus

TLDR
The characterization of the different enzymes, receptors, and nucleoside transporters in both X. laevis and X. tropicalis are reported and a thorough expression analysis of these members during development and in the adult frog reveals that each member displays distinct specific expression patterns.
...

References

SHOWING 1-10 OF 169 REFERENCES

The Effect of Inorganic Phosphate on the Activity of Bacterial Ribokinase

TLDR
Evidence is presented that the catalytic activity of E. coli ribokinase is also affected by PVI, increasing both the velocity and affinity of the enzyme for d-ribose, suggesting that a common mechanism for activity is shared among PfkB family members.

Cloning of human adenosine kinase cDNA: sequence similarity to microbial ribokinases and fructokinases.

TLDR
Adenosine kinase is a structurally distinct mammalian nucleoside kinase that appears to be akin to sugar kinases of microbial origin and set it apart from this family of structurally and functionally related proteins.

Inhibition of adenosine kinase by phosphonate and bisphosphonate derivatives

TLDR
The results indicate that the enzyme AK provides an additional cellular target for the clinically widely used bisphosphonates and related compounds, which could possibly be exploited for a new therapeutic application.

Hypothesis: structures, evolution, and ancestor of glucose kinases in the hexokinase family.

TLDR
It is demonstrated that both GMK and ecoGK are structurally homologous with glucose kinases in group HK, and that glucose kinase belonging to groups HK, A, and B in the HK family evolved divergently from a common ancestor.

Induced fit on sugar binding activates ribokinase.

TLDR
Evidence is presented that some types of movements of the lid are allowed in the ternary complex, which may be critical to the creation and breakdown of the transition state.

Deoxyribokinase from Salmonella typhimurium. Purification and properties.

Identification and Characterization of a Unique Adenosine Kinase from Mycobacterium tuberculosis

TLDR
The first bacterial AK to be characterized shows greater sequence homology with ribokinase and fructokinase than it does with other AKs, and may provide the molecular basis for the development of nucleoside analog compounds with selective activity against M. tuberculosis.

Pentavalent ions dependency of mammalian adenosine kinase.

  • W. HaoR. Gupta
  • Biology
    Biochemistry and molecular biology international
  • 1996
TLDR
Observations suggest that the pentavalent ions such as phosphate may be playing an important role in the enzyme's catalytic mechanism by facilitating either binding of adenosine to the enzyme or in the formation of an enzyme-ATP-adenosine complex.

Activation of ribokinase by monovalent cations.

TLDR
It is reported here that Escherichia coli ribokinase is activated by potassium with an apparent K(d) of 5 mM; the enzyme should therefore be fully activated under physiological conditions.
...