Adenosine kinase, glutamine synthetase and EAAT2 as gene therapy targets for temporal lobe epilepsy

@inproceedings{Young2014AdenosineKG,
  title={Adenosine kinase, glutamine synthetase and EAAT2 as gene therapy targets for temporal lobe epilepsy},
  author={Deborah Young and Dahna Fong and Patricia A. Lawlor and Angela Xiao Wu and Alexandre Mouravlev and Michelle McRae and Michelle Glass and Mike Dragunow and Matthew John During},
  booktitle={Gene Therapy},
  year={2014}
}
Astrocytes are an attractive cell target for gene therapy, but the validation of new therapeutic candidates is needed. We determined whether adeno-associated viral (AAV) vector-mediated overexpression of glutamine synthetase (GS) or excitatory amino-acid transporter 2 (EAAT2), or expression of microRNA targeting adenosine kinase (miR-ADK) in hippocampal astrocytes in the rat brain could modulate susceptibility to kainate-induced seizures and neuronal cell loss. Transgene expression was found… CONTINUE READING
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