Adenosine inhibits excitatory but not inhibitory synaptic transmission in the hippocampus.

  title={Adenosine inhibits excitatory but not inhibitory synaptic transmission in the hippocampus.},
  author={Kyeng Won Yoon and Steve Rothman},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  volume={11 5},
We examined the effects of adenosine and baclofen on inhibitory (IPSC) and excitatory (EPSC) synaptic currents in dissociated rat hippocampal neurons. Adenosine dramatically reduced monosynaptic EPSCs but failed to diminish IPSCs. This selective effect on EPSCs is likely due to inhibition of excitatory transmitter release because adenosine did not directly alter any properties of postsynaptic neurons. Baclofen depressed both EPSCs and IPSCs to approximately the same extent. These experiments… CONTINUE READING


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