Adenosine inhibits cytokine release and expression of adhesion molecules by activated human endothelial cells.

@article{Bouma1996AdenosineIC,
  title={Adenosine inhibits cytokine release and expression of adhesion molecules by activated human endothelial cells.},
  author={Maarten G Bouma and Frans A J M van den Wildenberg and Wim A. Buurman},
  journal={The American journal of physiology},
  year={1996},
  volume={270 2 Pt 1},
  pages={C522-9}
}
Ischemia induces excessive ATP catabolism with subsequent local release of its metabolite adenosine, an autacoid with anti-inflammatory properties. Because activation of the vascular endothelium is critical to the inflammatory host response during ischemia and reperfusion, the effects of adenosine on two major determinants of endothelial cell activation (i.e., the release of proinflammatory cytokines and the expression of adhesion molecules) were studied. Adenosine dose dependently inhibited… CONTINUE READING