Adenosine inhibits activation-induced T cell expression of CD2 and CD28 co-stimulatory molecules: role of interleukin-2 and cyclic AMP signaling pathways.

@article{Butler2003AdenosineIA,
  title={Adenosine inhibits activation-induced T cell expression of CD2 and CD28 co-stimulatory molecules: role of interleukin-2 and cyclic AMP signaling pathways.},
  author={Jared J. Butler and Jamie S. Mader and Carrie L Watson and Hong Zhang and Jonathan Blay and David W. Hoskin},
  journal={Journal of cellular biochemistry},
  year={2003},
  volume={89 5},
  pages={975-91}
}
Adenosine is an immunosuppressive molecule that is associated with the microenvironment of solid tumors. Mouse T cells activated with anti-CD3 antibody in the presence of adenosine with or without coformycin (to prevent adenosine breakdown by adenosine deaminase) exhibited decreased tyrosine phosphorylation of some intracellular proteins and were inhibited… CONTINUE READING