Adenosine inhibits GABAergic and glycinergic transmission in adult rat substantia gelatinosa neurons.

@article{Yang2004AdenosineIG,
  title={Adenosine inhibits GABAergic and glycinergic transmission in adult rat substantia gelatinosa neurons.},
  author={Kun Yang and Tsugumi Fujita and Eiichi Kumamoto},
  journal={Journal of neurophysiology},
  year={2004},
  volume={92 5},
  pages={
          2867-77
        }
}
The effect of adenosine on inhibitory postsynaptic currents (IPSCs) was examined in substantia gelatinosa (SG) neurons of adult rat spinal cord slices by using the whole cell patch-clamp technique. Adenosine reversibly reduced the amplitude of GABAergic and glycinergic electrically evoked IPSCs (eIPSCs) in a dose-dependent manner (EC50 = 14.5 and 19.1 microM, respectively). The A1 adenosine-receptor agonist N6-cyclopentyladenosine also reduced the eIPSCs, whereas the A1 antagonist 8-cyclopentyl… CONTINUE READING

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