Adenosine-induced suppression of synaptic responses and the initiation and expression of long-term potentiation in the CA1 region of the hippocampus.

@article{Mitchell1993AdenosineinducedSO,
  title={Adenosine-induced suppression of synaptic responses and the initiation and expression of long-term potentiation in the CA1 region of the hippocampus.},
  author={J B Mitchell and Kristin K Miller and Thomas V. Dunwiddie},
  journal={Hippocampus},
  year={1993},
  volume={3 1},
  pages={77-86}
}
The results of several previous studies have suggested that pretreatment with adenosine can block the induction of long-term potentiation (LTP), although other studies have found no effect of adenosine on the induction of LTP. The interaction of adenosine with the induction of LTP in the rat hippocampal slice was investigated. Inhibition of synaptic responses by adenosine either prior to or immediately after high-frequency or theta-burst stimulation did not affect LTP measured after washout of… CONTINUE READING