Adenosine-induced bronchoconstriction and its inhibition by nedocromil sodium.

@article{Church1993AdenosineinducedBA,
  title={Adenosine-induced bronchoconstriction and its inhibition by nedocromil sodium.},
  author={M. Church and S. Holgate},
  journal={The Journal of allergy and clinical immunology},
  year={1993},
  volume={92 1 Pt 2},
  pages={
          190-4
        }
}
The inhalation of adenosine or adenosine-5'-monophosphate (AMP) causes a reproducible and transient bronchoconstriction in both atopic and nonatopic asthmatic subjects that is not followed by a late-phase response. The response may be prevented by prophylactic treatment with histamine H1-receptor antagonist, local anesthetics, and atropine, which suggests that both mast cell mediator release and neuronal reflexes are involved. Adenosine- and AMP-induced bronchoconstriction are both blocked by… Expand
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