Adenosine-induced activation of esophageal nociceptors.

@article{Ru2011AdenosineinducedAO,
  title={Adenosine-induced activation of esophageal nociceptors.},
  author={Fei Ru and Lenka Surdenikova and Mariana Brozmanova and Marian Kollarik},
  journal={American journal of physiology. Gastrointestinal and liver physiology},
  year={2011},
  volume={300 3},
  pages={
          G485-93
        }
}
Clinical studies implicate adenosine acting on esophageal nociceptive pathways in the pathogenesis of noncardiac chest pain originating from the esophagus. However, the effect of adenosine on esophageal afferent nerve subtypes is incompletely understood. We addressed the hypothesis that adenosine selectively activates esophageal nociceptors. Whole cell perforated patch-clamp recordings and single-cell RT-PCR analysis were performed on the primary afferent neurons retrogradely labeled from the… CONTINUE READING

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