Adenosine-induced K+ current in Xenopus oocyte and the role of adenosine 3',5'-monophosphate.

@article{Lotan1985AdenosineinducedKC,
  title={Adenosine-induced K+ current in Xenopus oocyte and the role of adenosine 3',5'-monophosphate.},
  author={Ilana Lotan and Nathan Dascal and Y Oron and Sasson Cohen and Yoram Lass},
  journal={Molecular pharmacology},
  year={1985},
  volume={28 2},
  pages={170-7}
}
Voltage clamp technique was used in Xenopus laevis oocytes in order to study and compare membrane currents evoked by extracellularly applied adenosine (0.1-10 microM) and intracellularly injected cyclic AMP (0.15-10 microM). The adenosine response is a late long-lasting outward K+ current ("H" current), mediated by the Ra purine receptor subtype. The H current amplitude is directly proportional to (occupancy)3; the KD for adenosine is 3.34 microM. The H current is inhibited by the intracellular… CONTINUE READING

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