Adenosine increases anagen hair growth and thick hairs in Japanese women with female pattern hair loss: A pilot, double‐blind, randomized, placebo‐controlled trial

  title={Adenosine increases anagen hair growth and thick hairs in Japanese women with female pattern hair loss: A pilot, double‐blind, randomized, placebo‐controlled trial},
  author={H. Oura and Masato Iino and Y. Nakazawa and M. Tajima and R. Ideta and Y. Nakaya and S. Arase and J. Kishimoto},
  journal={The Journal of Dermatology},
Adenosine upregulates the expression of vascular endothelial growth factor and fibroblast growth factor‐7 in cultured dermal papilla cells. It has been shown that, in Japanese men, adenosine improves androgenetic alopecia due to the thickening of thin hair due to hair follicle miniaturization. To investigate the efficacy and safety of adenosine treatment to improve hair loss in women, 30 Japanese women with female pattern hair loss were recruited for this double‐blind, randomized, placebo… Expand
Topical adenosine increases the proportion of thick hair in Caucasian men with androgenetic alopecia
Adenosine is effective in increasing the proportion of thick hair in Caucasian men with AGA as well as in Japanese men and women. Expand
A New Strategy Increases Hair Growth – Combination of Topical Adenosine and Caffeine Hair Tonic
Male pattern hair loss (MPHL) and female pattern hair loss (FMPL) are important issues in cosmetic dermatology. The efficacy of hair tonic product containing 0.75% adenosine and 1.5% caffeine wasExpand
Adenosine stimulates growth of dermal papilla and lengthens the anagen phase by increasing the cysteine level via fibroblast growth factors 2 and 7 in an organ culture of mouse vibrissae hair follicles.
The results suggest that adenosine stimulates growth of hair follicles by triggering the expression of growth factors and β-catenin, and by inducing their downstream target signaling pathways, including the ERK pathway. Expand
Topical adenosine increases thick hair ratio in Japanese men with androgenetic alopecia
The objective of this study was to evaluate the hair growth efficacy and safety of topical adenosine in men with androgenetic alopecia. Expand
Evidence‐based treatments for female pattern hair loss: a summary of a Cochrane systematic review
Assessment of the evidence for the effectiveness and safety of the treatments available for female pattern hair loss found that a greater proportion of participants treated with minoxidil reported a moderate increase in their hair regrowth compared with placebo. Expand
Regenerative medicine and hair loss: how hair follicle culture has advanced our understanding of treatment options for androgenetic alopecia.
Advances in cell culture techniques that have led to a wider range of potential therapeutics to promote hair growth are discussed, in addition to detailing current knowledge on follicular cell implantation, and the challenges in making this approach a reality. Expand
Hair Physiology (Hair Growth, Alopecia, Scalp Treatment, etc.)
“Hair” refers to the hair shaft and follicle, and “hair follicles” are located under the skin dermis, where control hair growth with hair cycle, and certain agents have successfully introduced into market as quasi-drugs, with safety and certain efficacy data. Expand
Interventions for female pattern hair loss.
It is indicated that a greater proportion of participants treated with minoxidil reported a moderate to marked increase in their hair regrowth when compared with placebo, and there was an important increase of 13.18 in total hair count per cm² in the minxidil group compared to the placebo group. Expand
Human Hair Follicle: An Update on Biology and Perspectives in Hair Growth Disorders Treatment
The Hair Follicle is a vital component of mammalian skin and represents a unique, highly regenerative system that undergoes phases of rapid growth, regression, and resting periods and the key elements of cycle control have not been identified. Expand
Efficacy and Safety of a New Topical Hair Loss-Lotion Containing Oleanolic Acid, Apigenin, Biotinyl Tripeptide-1, Diaminopyrimidine Oxide, Adenosine, Biotin and Ginkgo biloba in Patients with Androgenetic Alopecia and Telogen effluvium: A Six-month Open-Label Prospective Clinical Study
This lotion enriched with a mixture of oleanolic acid, apigenin, biotinyl tripeptide-1, 2-4 diamino pyrimidine-3-oxide, adenosine, Ginkgo biloba, and biotin is safe and effective as a topical hair-loss treatment, as proven by the statistically significant increase in total hair fibers and anagen hairs, the increased thickness and scalp coverage on dermatological assessment, and patient self-assessment. Expand


Quantitative estimation of hair growth. I. androgenetic alopecia in women: effect of minoxidil.
The total weight from a defined area is recommended to be considered as the primary quantitative estimator for hair growth because it is not only easier to obtain, but less prone to error during sampling and measurement. Expand
Quantitative evaluations of male pattern baldness.
Several methods for the evaluation of hair growth have been reported; however, none of the hitherto reported methods are satisfactory as unbiased double blind studies to evaluate the efficacy of hairExpand
Characteristic features of Japanese women's hair with aging and with progressing hair loss.
In Japanese middle-aged women, hair density declined with age without the appearance of hair loss, which might be reduction of hair density and the ratio of thick hairs, but not an increase of vellus-like hairs. Expand
Phototrichogram analysis of Japanese female subjects with chronic diffuse hair loss.
Hair growth patterns of 101 Japanese female subjects with diffuse, chronic hair loss and 58 healthy Japanese female volunteers were categorized into subgroups using noninvasive quantitative methodsExpand
A hair growth questionnaire for use in the evaluation of therapeutic effects in men
A questionnaire to measure patient-perceived changes in hair growth and appearance in clinical trials of medical intervention for androgenetic alopecia in men is developed and evaluated. Expand
Androgen‐inducible TGF‐β1 from balding dermal papilla cells inhibits epithelial cell growth: a clue to understanding paradoxical effects of androgen on human hair growth
It is suggested that androgen‐inducible TGF‐β1 derived from DPCs of AGA is involved in epithelial cell growth suppression in the coculture system, providing the clue to understand the paradoxical effects of androgens for human hair growth. Expand
The unit area trichogram in the assessment of androgen‐dependent alopecia
The unit area trichogram was defined in the frontal and occipital areas often normal men and ten normal women and the results compared with the findings in ten male and fifteen female patients withExpand
Disorders of hair growth : diagnosis and treatment
This book discusses the embryology and anatomy of the hair follicle, clinical tools for assessing hair growth, and the genetic and physical causes of hair loss, and scalp conditions of significance. Expand
Minoxidil-induced hair growth is mediated by adenosine in cultured dermal papilla cells: possible involvement of sulfonylurea receptor 2B as a target of minoxidil.
The results indicate that the effect of minoxidil is mediated by adenosine, which triggers intracellular signal transduction via bothAdenosine A1 and A2 receptors, and that the expression of sulfonylurea receptor 2B in dermal papilla cells might play a role in the production of adenosines. Expand
Use of topical minoxidil in the treatment of male pattern baldness.
  • R. Savin
  • Medicine
  • Journal of the American Academy of Dermatology
  • 1987
This 12-month, double-blind, randomized study evaluated the safety and efficacy of topical minoxidil in the treatment of male pattern baldness with significant regrowth of nonvellus hairs in the patients using the 2% and 3% solutions. Expand