Adenosine in the spinal cord and periphery: release and regulation of pain.

@article{Sawynok2003AdenosineIT,
  title={Adenosine in the spinal cord and periphery: release and regulation of pain.},
  author={Jana Sawynok and Xue Jun Liu},
  journal={Progress in neurobiology},
  year={2003},
  volume={69 5},
  pages={313-40}
}
In the central nervous system (CNS), adenosine is an important neuromodulator and regulates neuronal and non-neuronal cellular function (e.g. microglia) by actions on extracellular adenosine A(1), A(2A), A(2B) and A(3) receptors. Extracellular levels of adenosine are regulated by synthesis, metabolism, release and uptake of adenosine. Adenosine also regulates pain transmission in the spinal cord and in the periphery, and a number of agents can alter the extracellular availability of adenosine… CONTINUE READING
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