Adenosine deaminase inhibitor in cardioplegia enhanced function preservation of the hypothermically stored rat heart.

@article{Zhu1994AdenosineDI,
  title={Adenosine deaminase inhibitor in cardioplegia enhanced function preservation of the hypothermically stored rat heart.},
  author={Qingyuan Zhu and X Yang and Martin A. Claydon and G. L. Hicks and Tian-ming Wang},
  journal={Transplantation},
  year={1994},
  volume={57 1},
  pages={35-40}
}
Adenosine (ADO) has been shown to be protective to the ischemic-reperfused myocardium. This study tested the hypothesis that inhibition of myocardial adenosine deaminase during cold storage will elevate tissue ADO content, improve the cardiac function, and preserve ATP. The isolated rat hearts (6-9 hearts/group) were flushed with a cardioplegic solution containing 0-75 microM erythro-9-(2-hydroxy-3-nonyl)adenine (EHNA) and immersion-stored at 0 degree C for 9 hr. Function was assessed after 30… CONTINUE READING